Heart failure & cardiomyopathies
Pregnancy-Induced Hypertensive Disorder and Risks of Future Ischemic and Nonischemic Heart Failure
Authors' conclusion
Pregnancy-induced hypertensive disorder is associated with an increased short-term and long-term risk of incident ischemic and nonischemic heart failure. Disease characteristics indicating more severe forms of pregnancy-induced hypertensive disorder amplify the heart failure risks.
Study context
- Population
- Primiparous women without a history of CVD in the Swedish Medical Birth Register, 1988–2019matched cohort
- Participants
- 79,334 vs 396,531
- Exposure
- Pregnancy-induced hypertensive disorder vs normotensive pregnancy
- Pregnancy-induced hypertensive disordern = 79,334
- Normotensive pregnanciesn = 396,531reference
- Outcome
- Incident HF, classified as ischemic or nonischemic
- Follow-up
- Median 13 years
Methodological detailsSwedish Medical Birth Register
- Swedish Medical Birth Register
Main finding
As reported in the abstract
Pregnancy-induced hypertensive disorder vs Normotensive pregnanciesAdjusted hazard ratio (95% CI)
HF overall
1.70(1.51–1.91)
Ischemic HF
2.28(1.74–2.98)
Nonischemic HF
1.60(1.40–1.83)
Observational data: associations, not effects.
Further findings
HF rates by disease severity
- Disease characteristics indicating severe hypertensive disorder were associated with higher HF rates
Timing of HF risk
- Rates highest within the first years after the hypertensive pregnancy but remained significantly increased thereafter
Original publication
Pregnancy-Induced Hypertensive Disorder and Risks of Future Ischemic and Nonischemic Heart Failure. JACC Heart Fail. Published 10 May 2023. doi:10.
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