Arrhythmias & electrophysiology
Characterization of sedation strategies in real-world use of pulsed field ablation Sub-analysis of the EU-PORIA registry
Authors' conclusion
AF ablation using deep sedation with the pentaspline PFA catheter demonstrated a safety and efficacy profile consistent with procedures performed under general anesthesia.
Study context
- Population
- Patients undergoing atrial fibrillation (AF) ablation with the pentaspline pulsed field ablation (PFA) catheter
- Participants
- 1,233 patients
- Comparison
- Deep sedation vs general anesthesia for AF ablation with the pentaspline PFA catheter
- Deep sedationn = 983
- General anesthesian = 250reference
Methodological detailsall-comer registry, consecutive patients, 7 high-volume European centres
- All-comer registry
- Consecutive patients
- 7 high-volume European centres
Primary result
As reported in the abstract
Freedom from recurrent AF/atrial tachycardia (AT) (episode >30s) · 1 year
P = 0.87
Further findings
PVI-only
P < 0.01
3D mapping use
P < 0.01
Procedure time · spread printed in brackets, kind not stated
P < 0.01
Fluoroscopy time · spread printed in brackets, kind not stated
P < 0.01
Safety
- No differences in incidence of serious adverse events
Original publication
Characterization of sedation strategies in real-world use of pulsed field ablation Sub-analysis of the EU-PORIA registry. Europace. Published 17 November 2025. doi:10.
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