Arrhythmias & electrophysiology
Chlorhexidine gluconate pocket lavage to prevent cardiac implantable electronic device infection in high-risk procedures
Main finding · CIED-related infectionResult — go to the resultHazard ratio 0.138 95% CI 0.04–0.45Authors' conclusion
CHG lavage during high-risk procedures was associated with a reduction in CIED-related infections without any adverse events reported.
Study context
- Population
- Patients undergoing high-risk CIED procedures (eg, generator change, device upgrade, lead/pocket revision)
- Participants
- 1,504 patients
- Exposure
- Chlorhexidine gluconate (CHG) pocket lavage vs normal saline (NS) irrigation only
- CHGn = 904
- NSn = 600reference
- Outcome
- CIED-related infection
- Follow-up
- 12 months
Methodological detailsmulticentre registry, propensity-score matched analysis
- Multicentre registry
- Propensity-score matched analysis
Main finding
As reported in the abstract
Hazard ratio
0.138
95% CI 0.04–0.45
P = 0.001
Events by group
CHGvs NS
HR 0.138 (95% CI 0.04–0.45); P = 0.001
Observational data: associations, not effects.
Secondary outcomes
| Outcome | CHG | NS | HR (95% CI) | P value | |
|---|---|---|---|---|---|
| CIED-related infection, PSM analysisCox · propensity-score matched | 0.2% | 2.5% | 0.08 (0.01–0.59) | P = 0.014 | |
| 0.050.21520Hazard ratio (log scale) |
CIED infection during long-term follow-up
- Lower infection risk with CHG persisted
Safety
- CHG-associated adverse events (primary safety outcome)
- 0 · events
Original publication
Chlorhexidine gluconate pocket lavage to prevent cardiac implantable electronic device infection in high-risk procedures. Heart Rhythm. Published 19 August 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →