Arrhythmias & electrophysiology
Efficacy of a gentamycin-collagen sponge to prevent infections in patients with an implantable cardioverter defibrillator undergoing device replacement or lead revision: Results of a monocentric ICD registry observational study
Authors' conclusion
The additional use of a GCS was associated with a lower incidence of device infections than standard-of-care infection prevention strategies alone.
Study context
- Population
- ICD patients who underwent elective device replacement, system upgrade, or lead revision between 2017 and April 2024consecutive ICD patients analyzed
- Participants
- 507 patients
- Exposure
- Cardiac device infection rate with and without the use of a gentamycin-collagen sponge (GCS)
- GCS groupn = 277
- Control groupn = 230reference
- Outcome
- Kaplan-Meier estimated infection rate
- Follow-up
- 1 year
Methodological detailsprospective single-center ICD registry, consecutive patients
- Prospective single-center ICD registry
- Consecutive patients
Main finding
As reported in the abstract
P = 0.005
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Device infection during follow-up (use of GCS as independent predictor)Lower device infection rate with GCS | 0.23 (0.07–0.84) | |
| 0.050.21520Hazard ratio (log scale) |
Baseline characteristics
- Similar between both groups
Original publication
Efficacy of a gentamycin-collagen sponge to prevent infections in patients with an implantable cardioverter defibrillator undergoing device replacement or lead revision: Results of a monocentric ICD registry observational study. Heart Rhythm. Published 18 March 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →