Valvular & structural heart disease
Chronic Conditions and Patient-Centered Outcomes After Transcatheter Aortic Valve Intervention
Main finding · 1-year mortalityResult — go to the resultAdjusted hazard ratio 2.33 95% CI 2.22–2.44Authors' conclusion
Chronic conditions are associated with worse survival after TAVI. However, most patients with high MCC are alive 1 year after treatment, and quality of life improvements appear independent of chronic disease burden.
Study context
- Population
- Patients undergoing transcatheter aortic valve intervention (TAVI) in the STS/ACC TVT registry linked to Medicare claims
- Participants
- 188,629 TAVI procedures
- Exposure
- High MCC vs low MCC
- Outcome
- Mortality
- Follow-up
- 1 year
Methodological detailsregistry linked to Medicare claims
- Registry linked to Medicare claims
Main finding
1-year mortality
Adjusted hazard ratio
2.33
95% CI 2.22–2.44
High MCCvs Low MCC
adjusted HR 2.33 (95% CI 2.22–2.44)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | High MCC | Low MCC | Standardized difference | P value |
|---|---|---|---|---|
| Kansas City Cardiomyopathy Questionnaire score at baselineMedian | 37.5 (IQR 21.4–56.8) | 55.7 (IQR 37.5–75.0) | P < 0.001 | |
| Change in Kansas City Cardiomyopathy Questionnaire score after TAVIMedian score change | 28.7 (IQR 9.9–48.4) | 24.5 (IQR 8.3–42.2) | +13.8% |
Change in Kansas City Cardiomyopathy Questionnaire score after TAVI
- Large improvement, appeared independent of chronic disease burden
Palliative care encounters
- Palliative care encounters (all patients)
- 8,946, 4.7%
- Range across centres
- 0% to 25% of cases
Original publication
Chronic Conditions and Patient-Centered Outcomes After Transcatheter Aortic Valve Intervention. JACC Adv. Published 17 October 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →