Valvular & structural heart disease
Circulating miRNA in Functional Tricuspid Regurgitation. Unveiling Novel Links to Heart Failure: A Pilot Study
An erratum to this article was published (ESC Heart Fail, Dec 2025 ↗)
Authors' conclusion
Circulating miRNAs are novel diagnostic and prognostic biomarkers in severe FTR. The quantification of miR-186-5p, miR-30e-5p, and miR-152-3p held strong diagnostic value, and the quantification of miR-15a-5p and miR-92a-3p are independently associated with outcomes.
Study context
- Population
- Consecutive outpatients with isolated severe functional tricuspid regurgitation (FTR) evaluated in a Heart Valve Clinicvalidation: FTR 92, controls 42
- Participants
- 100 vs 50
- Comparison
- Isolated severe FTR vs no TR
- FTRn = 100
- Controlsn = 50reference
- Outcome
- Combined endpoint of HF hospital admission and all-cause mortality
- Follow-up
- Median 20.4 months (IQR 8-35 months)
Methodological detailspilot study, age- and gender-matched controls, screening and validation phases, Bioinformatics analysis to predict target genes and pathways, Screening by miRNA array profiling of 192 microRNAs (miRNAs) (qRT-PCR), FTR n = 8 vs controls n = 8; validation by qRT-PCR
- Pilot study
- Age- and gender-matched controls
- Screening and validation phases
- Bioinformatics analysis to predict target genes and pathways
- Screening by miRNA array profiling of 192 miRNAs (qRT-PCR), FTR n = 8 vs controls n = 8; validation by qRT-PCR
Main finding
As reported in the abstract
Diagnostic value of miRNAs for FTR
| Group | AUC |
|---|---|
| miR-186-5p | 0.93 (0.88-0.97) |
| miR-30e-5p | 0.83 (0.75-0.91) |
| miR-152-3p | 0.84 (0.76-0.92) |
AUC
miR-186-5p0.93 (0.88-0.97)
miR-30e-5p0.83 (0.75-0.91)
miR-152-3p0.84 (0.76-0.92)
Observational data: associations, not effects.
Further findings
Combined endpoint (heart failure (HF) admission and all-cause mortality) in FTR · median follow-up 20.4 months (IQR 8-35 months)
| FTR | HR (CI) | P value | ||
|---|---|---|---|---|
| miR-15a-5pAdjusted for age, gender, NYHA class | 32% | 0.21 (0.06–0.649) | P = 0.007 | |
| miR-92a-3pAdjusted for age, gender, NYHA class | 0.27 (0.09–0.76) | P = 0.01 | ||
| 0.050.21520Hazard ratio (log scale) |
- Combined endpoint (HF admission and all-cause mortality) in FTR — Low expression of miR-15a-5p, miR-92a-3p, miR101-3p, miR-363-3p, miR-324-3p and miR-22-3p: significantly higher event rates (log-rank)
- P < 0.01
Original publication
Circulating miRNA in Functional Tricuspid Regurgitation. Unveiling Novel Links to Heart Failure: A Pilot Study. ESC Heart Fail. Published 18 April 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →