Valvular & structural heart disease
STREI: a new index of right heart function in isolated severe tricuspid regurgitation by speckle-tracking echocardiography
Main finding · Composite endpointResult — go to the resultAdj HR 1.89 CI 1.4–2.34Authors' conclusion
STREI index is a novel parameter of RV performance that independently predicts CV events. The combination of RA and RV strain stratifies better patients' risk, reflecting a broader effect of TR on right heart chambers.
Study context
- Population
- Patients with ≥severe tricuspid regurgitation (TR) evaluated in a Heart Valve Clinic176 finally included
- Participants
- 300 patients
- Exposure
- STREI stratification for cardiovascular (CV) outcome prediction
- Outcome
- Composite of:
- HF hospital admission
- All-cause mortality
- Follow-up
- Median 2.2 years (IQR 12-41 months)
Methodological detailsconsecutive patients, external validation cohort
- Consecutive patients
- External validation cohort
Main finding
Composite endpoint · median 2.2 years
Adj HR
1.89
CI 1.4–2.34
P < 0.001
STREI stratification (per stratum)
adj HR 1.89 (CI 1.4–2.34); P < 0.001
Per stratum, as printed
As reported in the abstract
- Patients reaching the composite endpoint
- 38%
Observational data: associations, not effects.
Further findings
Right ventricular (RV) dysfunction detection
- STREI index identified a higher percentage of patients with RV dysfunction than conventional parameters
External validation cohort
- Pre-defined cut-offs achieved similar prognostic performance (n = 50)
Original publication
STREI: a new index of right heart function in isolated severe tricuspid regurgitation by speckle-tracking echocardiography. Eur Heart J Cardiovasc Imaging. Published 13 November 2023. doi:10.
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