Valvular & structural heart disease
Clinical and echocardiographic parameters associated with outcomes in patients with moderate secondary mitral regurgitation
Authors' conclusion
In patients with moderate SMR, distinction in SMR aetiology and assessment of symptoms are important independent determinants of outcome.
Study context
- Population
- Patients with moderate secondary mitral regurgitation (SMR)
- Participants
- 1,061 patients
- Exposure
- New York Heart Association (NYHA) class III-IV vs I-II; SMR aetiology
- NYHA I-IIn = 854reference
- NYHA III-IVn = 207
- Atrial SMR (aSMR)n = 352reference
- Ventricular SMR (vSMR) left ventricular ejection fraction (LVEF) ≥40%n = 329
- vSMR LVEF <40%n = 380
- Outcome
- All-cause mortality
- Follow-up
- Median 82 (IQR 55-115) months
Methodological detailspropensity-score matched
- Propensity-score matched
Main finding
As reported in the abstract
Hazard ratio (95% CI)P value
NYHA III-IVvs NYHA I-IImultivariable; associated with both endpoints
1.578(1.244–2.002)
P < 0.001vSMR LVEF ≥40%vs aSMRmultivariable
1.528(1.108–2.106)
P = 0.010vSMR LVEF <40%vs aSMRmultivariable
1.960(1.434–2.679)
P < 0.001- Died during follow-up (overall)
- 397 (37%)
Observational data: associations, not effects.
Secondary outcomes
All-cause mortality or heart failure (HF) events
- HF events or death (overall)
- 539 (51%)
- NYHA class III-IV and SMR aetiology independently associated
Both endpoints after propensity-score matching
- NYHA class and SMR aetiology remained associated with both outcomes
- log rank p<0.050
- Matched for NYHA class and for SMR aetiology
Original publication
Clinical and echocardiographic parameters associated with outcomes in patients with moderate secondary mitral regurgitation. Heart. Published 4 October 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →