Heart failure & cardiomyopathies
Clinical and prognostic implications of left ventricular dilatation in heart failure
Authors' conclusion
The majority of patients with HF and LVEF < 50% present both increased LVEDDi and LVEDVi whereas 20% show discordant linear and volumetric definitions of LV dilatation. Patients with increased LVEDDi and LVEDVi have the worst clinical outcomes
Study context
- Population
- Patients with heart failure (HF) symptoms and LV ejection fraction (LVEF) < 50% undergoing CMR
- Participants
- 564 patients
- Exposure
- LV dilatation by left ventricular end-diastolic diameter index (LVEDDi) vs LVEDVi
- Outcome
- CV death or HF hospitalization
- Follow-up
- Median 2.8 years
Main finding
As reported in the abstract
Hazard ratio (95% CI)P value
Both dilated LVEDDi and LVEDVihighest cumulative event rate
3.00(1.15–7.81)
P = 0.024- LVEDDi · independently associated
- HR 3.29; P < 0.001
- LVEDVi · independently associated
- HR 2.8; P = 0.009
Observational data: associations, not effects.
Further findings
Correlation LVEDDi with LVEDVi
- Modest correlation (r)
- 0.682
- P
- P < 0.001
Prevalence of LV dilatation
- LVEDVi-based definition
- 84%
- LVEDDi-based definition
- 73%
- Discordant definitions
- 20%
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Clinical and prognostic implications of left ventricular dilatation in heart failure. Eur Heart J Cardiovasc Imaging. Published 21 January 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →