Heart failure & cardiomyopathies
Early Changes in Estimated Glomerular Filtration Rate Post-Initiation of Empagliflozin in EMPEROR-Preserved
Primary result · eGFR change from baseline to week 4Result — go to the resultMean eGFR change −3.2 ml/min/1.73 m²Authors' conclusion
Such small eGFR decrease was not associated with adverse cardiovascular outcomes with empagliflozin. In contrast, eGFR decrease was associated with poor cardiovascular outcomes with placebo.
Study context
- Population
- Patients with heart failure with preserved ejection fraction (HFpEF) enrolled in EMPEROR-Preserved97.5% with initial eGFR change
- Participants
- 5,836 patients
- Comparison
- Empagliflozin vs placebo, by early eGFR change
- Primary endpoint
- Composite of:
- HF hospitalization
- CV death (primary outcome)
- Follow-up
- After week 4
Methodological detailslandmark analysis
- Landmark analysis
Primary result
eGFR change from baseline to week 4
Mean eGFR change
−3.2 ml/min/1.73 m²
As reported in the abstract
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Outcomes after week 4, placebo: tertile with most profound eGFR decrease (≥5.1%) vs tertile with eGFR increaseeGFR decrease ≥5.1%vs eGFR increasePrimary outcome | 1.46 (1.17–1.82) | |
| Outcomes after week 4, placebo: tertile with most profound eGFR decrease (≥5.1%) vs tertile with eGFR increaseeGFR decrease ≥5.1%vs eGFR increaseCV mortality | 1.38 (1.01–1.89) | |
| Outcomes after week 4, placebo: tertile with most profound eGFR decrease (≥5.1%) vs tertile with eGFR increaseeGFR decrease ≥5.1%vs eGFR increaseSustained ≥50% eGFR decrease or ESRD | 2.20 (1.20–4.04) | |
| 0.20.5125Hazard ratio (log scale) |
Outcomes after week 4 by eGFR change tertile, empagliflozin
- Risk of primary outcome (HF hospitalization or CV death), CV and all-cause mortality, sustained ≥50% eGFR decrease or end-stage renal disease (ESRD) did not differ by eGFR change levels
Original publication
Early Changes in Estimated Glomerular Filtration Rate Post-Initiation of Empagliflozin in EMPEROR-Preserved. Eur J Heart Fail. Published 21 January 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →