Heart failure & cardiomyopathies
Myocardial Perfusion in Cardiac Amyloidosis
Authors' conclusion
Cardiac amyloidosis is associated with severe inducible myocardial ischaemia demonstrable by histology and CMR stress perfusion mapping.
Study context
- Population
- Patients with cardiac amyloidosis and controls without cardiac amyloidosis (CA) undergoing quantitative stress perfusion cardiovascular magnetic resonance (CMR) with myocardial blood flow (MBF) mapping97 without CA
- Participants
- 93 / 47 / 26 / 24
- Comparison
- CA vs 3VD, unobstructed coronary arteries and HV
- CAn = 93
- 3VDn = 47reference
- Unobstructed coronary arteriesn = 26reference
- HVn = 24reference
- Outcome
- Stress myocardial blood flow (MBF)
Methodological detailshistopathological assessment
- Histopathological assessment
Main finding
As reported in the abstract
Stress MBF
CA vs 3VD: P = 0.011 · CA vs Unobstructed coronary arteries: P < 0.001 · CA vs HV: P < 0.001
Further findings
Correlates of myocardial perfusion abnormalities
- Correlated with amyloid burden, systolic and diastolic function, structural parameters and blood biomarkers
- P < 0.05
Histopathology (24 biopsies, 3 explanted hearts)
- Abnormal VEGF staining in cardiomyocytes and endothelial cells, possibly related to hypoxia
- Amyloid infiltration in intramural arteries associated with severe lumen reduction and severe reduction in capillary density
Original publication
Myocardial Perfusion in Cardiac Amyloidosis. Eur J Heart Fail. Published 21 January 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →