Heart failure & cardiomyopathies
Clinical Characterization of Arrhythmia-Induced Cardiomyopathy in Patients With Tachyarrhythmia and Idiopathic Heart Failure
Authors' conclusion
We observed a high prevalence of AIC in patients with otherwise unexplained LVSD and concomitant tachyarrhythmia, suggesting that this condition may be underdiagnosed in clinical practice. Most patients recovered fast, within months, from LVSD. A low initial LV end-diastolic diameter may constitute an early marker for diagnosis of AIC.
Study context
- Population
- Patients with newly diagnosed, otherwise unexplained left ventricular (LV) systolic dysfunction and tachyarrhythmia, after effective rhythm restorationrecurred arrhythmia excluded
- Participants
- 50 patients
- Exposure
- Arrhythmia-induced cardiomyopathy (AIC) vs non-AIC
- AICn = 41
- Outcome
- Relative frequency of pure AIC
- Follow-up
- 6 months after rhythm restoration
Methodological detailsFollow-up at 2, 4 and 6 months with clinical characteristics, biomarkers and cardiac imaging including CMR
- Follow-up at 2, 4 and 6 months with clinical characteristics, biomarkers and cardiac imaging including CMR
Main finding
As reported in the abstract
AIC diagnosis
AIC
41
events
Observational data: associations, not effects.
Further findings
| Outcome | AIC | non-AIC |
|---|---|---|
| LVEF, baseline to month 2 · 2 months | 52.7% (SD 8.0%) | 43.3% (SD 7.0%) |
| Baseline LVEF | 35.4% ± 8.2% | 37.0% ± 9.5% |
| LVEF, month 2 to 6 · 6 months | 57.2% (SD 6.1%) | 44.0% (SD 7.8%) |
| P (month 2 to 6) | P < 0.001 | P = 0.628 |
LVEF, month 2 to 6 · 6 months
- Continued increase in AIC; stable in non-AIC
Early diagnostic parameters of AIC (multivariable logistic regression) · baseline
- Lower baseline LV end-diastolic diameter could be used for early diagnosis of AIC
- Biomarkers and other morphological or functional parameters, including late LV gadolinium enhancement, not suitable for early diagnosis
Original publication
Clinical Characterization of Arrhythmia-Induced Cardiomyopathy in Patients With Tachyarrhythmia and Idiopathic Heart Failure. JACC Clin Electrophysiol. Published 13 March 2024. doi:10.
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