Heart failure & cardiomyopathies
Systemic Sclerosis is Associated with Increased In-Patient Mortality in Patients Hospitalized for Heart Failure
Authors' conclusion
In patients hospitalized for HF, those with SSc were noted to have higher odds of in-hospital mortality than those without SSc.
Study context
- Population
- Patients hospitalized with a primary diagnosis of heart failure (HF), US National Inpatient Sample, 2016–2019
- Participants
- 4,709,724 HF hospitalizations
- Exposure
- HF hospitalizations with vs without systemic sclerosis (SSc)
- SScn = 8,150
- Outcome
- In-hospital mortality
Methodological detailsNational Inpatient Sample 2016–2019, multivariable logistic regression
- National Inpatient Sample 2016–2019
- Multivariable logistic regression
Main finding
As reported in the abstract
SSc vs No SScEstimate (95% CI)P value
Unadjusted
OR 1.99(1.60–2.48)
P < 0.001Adjusted for confounders
adjusted OR 1.81(1.44–2.28)
P < 0.001Observational data: associations, not effects.
Further findings
| Outcome | SSc | No SSc | Adjusted mean difference (95% CI) | P value | |
|---|---|---|---|---|---|
| Length of stay | 6.4 | 5.4 | 0.37 (0.05–0.68) | P = 0.02 | |
| Hospitalization costs | $67 363 | $57 128 | 198.9 (−4780 to 5178) | P = 0.93 | |
| −50000500010000Difference (linear scale) |
Original publication
Systemic Sclerosis is Associated with Increased In-Patient Mortality in Patients Hospitalized for Heart Failure. ESC Heart Fail. Published 12 March 2024. doi:10.
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