Outcomes of intravascular imaging-guided percutaneous coronary intervention according to lesion complexity
Pooled result · Target vessel failure (TVF): composite of cardiac death, target vessel myocardial infarction, or target vessel revascularisationResult — go to the resultHazard ratio 1.59 95% CI 1.28–1.96Authors' conclusion
In patients with complex coronary artery lesions, IVI-guided PCI showed a lower risk of TVF across all degrees of lesion complexity. The prognostic benefit of IVI-guided PCI tended to increase as patients had more complex lesion features. (RENOVATE-COMPLEX-PCI [ClinicalTrials.gov: NCT03381872]; Institutional cardiovascular catheterisation database of the Samsung Medical Center [ClinicalTrials.gov: NCT03870815]).
Study context
- Population
- Patients with complex coronary artery lesions, classified according to the number of complex lesion features found in each patientpatients from the RENOVATE-COMPLEX-PCI trial and the institutional registry of the Samsung Medical Center · RENOVATE-COMPLEX-PCI trial 1,639 · institutional registry of the Samsung Medical Center 2,972
- Participants
- 4,611 patients
- Comparison
- ≥3 complex lesion features vs <3 complex lesion features
- Outcome
- Target vessel failure (TVF): composite of cardiac death, target vessel myocardial infarction, or target vessel revascularisation
- Follow-up
- 3 years
Pooled result
As reported in the abstract
Hazard ratio
1.59
95% CI 1.28–1.96
P < 0.001
By group
Further pooled results
| Outcome | IVI-guided PCI | Angiography-guided PCI | ≥3 complex lesion features | <3 complex lesion features | HR (95% CI) | P value | |
|---|---|---|---|---|---|---|---|
| TVF, patients with ≥3 complex lesion featuresIVI-guided PCI vs angiography-guided PCI | 7.4% | 14.4% | Not reported in the abstract | Not reported in the abstract | 0.49 (0.35–0.69) | P < 0.001 | ≥3 complex lesion features, <3 complex lesion features: not reported in the abstract |
| TVF, patients with <3 complex lesion featuresIVI-guided PCI vs angiography-guided PCI | 5.7% | 8.1% | Not reported in the abstract | Not reported in the abstract | 0.72 (0.53–0.98) | P = 0.039 | ≥3 complex lesion features, <3 complex lesion features: not reported in the abstract |
| 0.20.5125Hazard ratio (log scale) |
Absolute risk reduction for target vessel failure (TVF) with intravascular imaging (IVI)-guided percutaneous coronary intervention (PCI) by number of complex lesion features
- 1 complex lesion feature
- −0.012
- 2 complex lesion features
- −0.027
- 3 complex lesion features
- −0.055
- ≥4 complex lesion features
- −0.077
- Interaction p=0.048
Original publication
Summarised from the published abstract; every number is checked against it