Arrhythmias & electrophysiology
Sex difference in genetic risk in the prevalence of atrial fibrillation
Authors' conclusion
Our study is the first to show a sex difference in the association of AF-PRS and AF prevalence. AF-PRS is more closely associated with the prevalence of AF in men than in women.
Study context
- Population
- Participants of a community-based cohort study in Japanmean age 63.4 years, 5182, 30.7% men
- Participants
- 16,853 participants
- Exposure
- Sex differences in the association of AF-PRS with the prevalence of atrial fibrillation (AF)
- Menn = 5,182
- Outcome
- Prevalence of AF
Main finding
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | Men | Women | Odds ratio |
|---|---|---|---|
| AFMen | 8.2 | ||
| AFWomen | 9.4 | ||
| Area under the receiver operating characteristic curve for AF, integrating AF-PRS into the CHARGE-AF score | |||
| CHARGE-AF score | 0.639 | 0.710 | |
| CHARGE-AF score + AF-PRS | 0.749 | 0.733 |
Area under the receiver operating characteristic curve for AF, integrating AF-PRS into the Cohorts for Heart and Aging Research in Genomic Epidemiology Atrial Fibrillation (CHARGE-AF) score
- Significantly enhanced in men but not in women
Original publication
Sex difference in genetic risk in the prevalence of atrial fibrillation. Heart Rhythm. Published 23 March 2025. doi:10.
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