Clinical Relevance of Discordance Between Physiology- and Imaging-Guided Percutaneous Coronary Intervention (PCI) Strategies in Intermediate Coronary Stenosis
Authors' conclusion
Angiography-based physiological assessments can offer additional prognostic insights for patients undergoing IVI-guided PCI. IVUS-guided PCI may not be advantageous in patients with functionally insignificant lesions.
Study context
- Population
- Patients with intermediate coronary stenosis undergoing intravascular ultrasound (IVUS)-guided treatment decisions, with retrospective μQFR assessment
- Participants
- 784 patients
- Comparison
- Discordance between μQFR and IVUS-guided PCI decisions
- DEFERn = 270
- PERFORMn = 230reference
- REFERENCEn = 247
- Primary endpoint
- MACE:
- Death
- MI
- Target vessel revascularization
- Follow-up
- 24-month follow-up
Methodological detailspost hoc analysis, multicentre, international, μQFR performed retrospectively
- Post hoc analysis
- Multicentre
- International
- μQFR performed retrospectively
Primary result
As reported in the abstract
2 years
Each group vs PERFORMAdjusted hazard ratio (95% CI)P value
REFERENCE
2.46(1.13–5.35)
P = 0.023DEFER
0.88(0.37–2.11)
P = 0.779Further findings
Reclassification by physiological assessment among patients who underwent IVUS-guided PCI
- Patients undergoing IVUS-guided PCI reclassified by physiological assessment (negative μQFR with PCI)
- 48.2% (230/477)
Quality of life · 2 years
- Comparable among the 3 groups
- P = 0.198
Original publication
Clinical Relevance of Discordance Between Physiology- and Imaging-Guided PCI Strategies in Intermediate Coronary Stenosis. JACC Cardiovasc Interv. Published 18 December 2024. doi:10.
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