Prognostic Implications of Quantitative Flow Ratio and Plaque Characteristics in Intravascular Ultrasound–Guided Treatment Strategy
Primary result · TVF among deferred vesselsResult — go to the resultHazard ratio 4.54 95% CI 1.02–20.29Authors' conclusion
Among the IVUS-guided deferred group, vessels with qn-HRPC and ql-HRPC with low QFR (≤0.90) exhibited a significantly higher risk for TVF compared with those with ≤2 features.
Study context
- Population
- Vessels suitable for quantitative flow ratio (QFR) analysis in the intravascular ultrasound (IVUS)-guided strategy group of the FLAVOUR trial (intermediate lesions)vessels (46.1%) analyzable for QFR
- Participants
- 415 participants
- Comparison
- Deferred vessels with 3 high-risk features vs ≤2 high-risk features
- Primary endpoint
- Target vessel failure (TVF) (cardiac death, target vessel MI, target vessel revascularization)
Primary result
TVF among deferred vessels
Hazard ratio
4.54
95% CI 1.02–20.29
By group
3 high-risk featuresvs ≤2 high-risk features
HR 4.54 (95% CI 1.02–20.29)
As reported in the abstract
Further findings
Plaque characteristics by QFR
- Numbers of quantitative high-risk plaque characteristics (qn-HRPCs) and qualitative high-risk plaque characteristics (ql-HRPCs) increased with decreasing QFR
Original publication
Prognostic Implications of Quantitative Flow Ratio and Plaque Characteristics in Intravascular Ultrasound–Guided Treatment Strategy. JACC Cardiovasc Interv. Published 7 February 2024. doi:10.
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