Heart failure & cardiomyopathies
Clinical use of [15O]H2O/[18F]FDG viability positron emission tomography does not reliably predict left ventricular ejection fraction improvement or survival after revascularization
Authors' conclusion
No [15O]H2O/[18F]FDG PET parameters predicted post-revascularization LVEF improvement or survival in patients with suspected chronic iHF. Thus, the clinical use of PET viability imaging still warrants reconsideration, particularly if non-ischaemic HF is present.
Study context
- Population
- Patients with chronic ischaemic heart failure (iHF) and reduced left ventricular ejection fraction (LVEF) undergoing [15O]H2O/[18F]FDG PET viability imaging before potential revascularizationrevascularized patients analysed, of 73 who underwent [15O]H2O/[18F]FDG PET viability imaging · Underwent PET viability imaging Seventy-three · Revascularized 31 of 73 (42%)
- Participants
- 31 patientsEvents: 16 of 31 (52%) experiencing a ≥5% LVEF improvement postoperatively
- Predictors
- [15O]H2O/[18F]FDG PET metrics and baseline characteristics
- Predicted outcome
- ≥5% absolute increase in LVEF from baseline to follow-up, assessed by echocardiography; survival in revascularized patients
Model performance
As reported in the abstract
Area under curve of PET metrics to predict LVEF improvement
≤0.60
Further findings
Survival in revascularized patients
- No baseline characteristics or PET measures predicted survival in revascularized patients
Baseline LVEF
- Mean baseline LVEF
- 31 ± 9%
Baseline characteristics and revascularization type, improvers vs non-improvers
- Did not significantly differ between improvers and non-improvers
Original publication
Clinical use of [15O]H2O/[18F]FDG viability positron emission tomography does not reliably predict left ventricular ejection fraction improvement or survival after revascularization. Eur Heart J Cardiovasc Imaging. Published 4 February 2025. doi:10.
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