Heart failure & cardiomyopathies

Clinical Utility and Safety of Finerenone in Patients with Heart Failure: Rationale and Design of FINE Registry

ESC Heart FailPublished multicentre, observational registry

Study context

Population
Patients with previous history of decompensated heart failure (HF) and elevated natriuretic peptides (NPs), irrespective of ejection fraction
Planned comparison
Patients initiating finerenone vs 1:1 matched control cohort not receiving finerenone
Methodological detailsincluding regional and tertiary hospitals, 1:1 matched control cohort
  • Including regional and tertiary hospitals
  • 1:1 matched control cohort

No results yet. This paper sets out the design of a trial; its results are to come.

Further findings

Endpoints will include the incidence of HF exacerbations requiring intravenous therapy, hospitalizations, renal replacement therapy, and mortality due to cardiovascular or renal causes
  • Design paper; no results reported
  • Study design: follow-up at 6 and 12 months (and optional 3 and 5 years); endpoints include the incidence of HF exacerbations requiring intravenous therapy, hospitalizations, renal replacement therapy, and mortality due to cardiovascular or renal causes

Original publication

Clinical Utility and Safety of Finerenone in Patients with Heart Failure: Rationale and Design of FINE Registry. ESC Heart Fail. Published 28 February 2025. doi:10.1002/ehf2.15260

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