Heart failure & cardiomyopathies
Clinical Utility of Computed Tomography–Derived Myocardial Extracellular Volume Fraction: A Systematic Review and Meta-Analysis
Authors' conclusion
The high diagnostic accuracy of CT-ECV suggests the usefulness of CT-ECV in the diagnosis of cardiac amyloidosis in preoperative CT planning for transcatheter aortic valve replacement.
Study context
- Population
- Studies of computed tomography (CT)-derived myocardial ECV in CV diseases
- Comparison
- CT-derived ECV in controls vs AS vs cardiac amyloidosis
- Outcome
- CT-derived ECV compared among control, AS and cardiac amyloidosis cohorts
Pooled result
As reported in the abstract
Pooled CT-derived ECV
Aortic stenosis vs Control: P = 0.002 · Cardiac amyloidosis vs Aortic stenosis: P < 0.001
Further pooled results
| Outcome | Values |
|---|---|
| Diagnostic accuracy of CT-derived ECV for cardiac amyloidosis | CT-ECV Sensitivity 92.8% (95% CI: 86.7%-96.2%) · Specificity 84.8% (95% CI: 68.6%-93.4%) · AUC (summary ROC) 0.94 (95% CI: 0.88-1.00) |
Original publication
Clinical Utility of Computed Tomography–Derived Myocardial Extracellular Volume Fraction: A Systematic Review and Meta-Analysis. JACC Cardiovasc Imaging. Published 22 November 2023. doi:10.
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