Cardio-oncology & otherCohort study
Clonal Hematopoiesis and Risk of New-Onset Myocarditis and Pericarditis
- Prospective cohort study
- population-based
- UK Biobank
Authors' conclusion
In this study, CHIP was a strong risk factor for myocarditis and pericarditis among middle-aged adults.
Study context
- Population
- UK Biobank participants with whole-exome sequencing, no prevalent CVD or hematological malignancy; enrolled 2006–2010382 developed myocarditis or pericarditis
- Participants
- 335,426 participants
- Exposure
- Clonal hematopoiesis of indeterminate potential (CHIP) vs no CHIP
- Any CHIPn = 11,057
- Large CHIPn = 7,271
- Outcome
- Composite of:
- Incident myocarditis
- Pericarditis
- Follow-up
- Median 13.6 (IQR, 12.8-14.2) years
Main finding
As reported in the abstract
Incident myocarditis or pericarditis
Each group vs no CHIPMultivariable-adjusted HR (95% CI)P value
Any CHIP
1.75(1.14–2.68)
P = 0.01Large CHIP
2.07(1.28–3.33)
P = 0.003Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Pericarditis, DNMT3A CHIP | 2.22 (1.17–4.21) | P = 0.01 | |
| Myocarditis, TET2 CHIP | 3.65 (1.16–11.49) | P = 0.03 | |
| 0.050.21520Hazard ratio (log scale) |
| Outcome | fold risk (95% CI) | P value |
|---|---|---|
| Noncardiac immune-mediated inflammatory diseases · no evidence for reverse causation | 1.27 (1.16–1.39) | P < 0.001 |
Other CVD (eg, CAD, HF)
- CHIP associated with myocarditis and pericarditis more strongly than with other CVD
Original publication
Clonal Hematopoiesis and Risk of New-Onset Myocarditis and Pericarditis. JAMA Cardiol. Published 1 November 2025. doi:10.1001/jamacardio.2025.3369
Summarised from the published abstract; every number is checked against it