Impact of Exercise on Clonal Hematopoiesis
Authors' conclusion
Exercise was not associated with CH burden but does reduce excess ACM of CH in patients with cancer.
Study context
- Population
- Patients with cancer: solid tumors (MSK-IMPACT) and primary breast cancer (CANTO)3,539 MSK-IMPACT
- Exposure
- Exercisers vs nonexercisers
- Outcome
- CH prevalence and excess all-cause mortality (ACM) risk of CH
Methodological details2 retrospective cohorts (MSK-IMPACT, CANTO), multivariable analysis, prospective remotely-supervised structured exercise therapy study
- 2 retrospective cohorts (MSK-IMPACT, CANTO)
- Multivariable analysis
- Prospective remotely-supervised structured exercise therapy study
Main finding
As reported in the abstract
Estimate (95% CI)
Exercisersvs NonexercisersCH prevalence, MSK-IMPACT; adjusted Firth's logistic regression
OR 0.95(0.8–1.13)
Exercisersvs NonexercisersCH prevalence, CANTO; adjusted Firth's logistic regression
OR 1.28(0.89–1.84)
CH-exercisersvs Non-CH nonexercisersACM, adjusted
HR 0.69(0.55–0.87)
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| ACM, CHvs no CHUnadjusted | 1.41 (1.23–1.62) | |
| 0.512Hazard ratio (log scale) |
Prospective exercise study (n = 4, cancer and clonal hematopoiesis (CH))
- CV risk factors improved
- No changes in peripheral blood somatic variant allele frequency
Original publication
Impact of Exercise on Clonal Hematopoiesis. JACC Adv. Published 21 October 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →