Heart failure & cardiomyopathiesRandomised controlled trial
Pneumococcal vaccination incentive campaign in chronic heart failure patients in France: a cluster-randomized trial
- Cluster randomised controlled trial
- open-label
- pragmatic
Authors' conclusion
This randomized study demonstrated the effectiveness of a mail-in promotion to sustainably increase pneumococcal vaccination coverage in a frail high-risk population.
Study context
- Population
- Patients with chronic heart failure (HF) and their general practitioners (GPs) in a French region, identified through the regional health insurance database
- Participants
- 12,285 patients · 3,952 GPs
- Comparison
- Vaccination incentive letters vs observation
- Interventionn = 6,140
- Controln = 5,937reference
- Primary endpoint
- Pneumococcal vaccination rate
- Follow-up
- One year
Primary result
As reported in the abstract
- Multivariable analyses: higher rate of vaccination with the intervention
- 15-fold
Secondary outcomes
Factors associated with vaccine uptake
- Vaccination rate increased with male patients, female GP and previous influenza vaccination; decreased in patients <70 and >85 years
Original publication
Pneumococcal vaccination incentive campaign in chronic heart failure patients in France: a cluster-randomized trial. Eur J Prev Cardiol. Published 29 August 2025. doi:10.1093/eurjpc/zwaf529
Summarised from the published abstract; every number is checked against it