Heart failure & cardiomyopathies
Combining echo-derived haemodynamic phenotypes and myocardial strain for risk stratification of chronic heart failure with reduced ejection fraction
Authors' conclusion
There was a continuum in LV-GLS impairment across the spectrum of haemodynamic phenotypes and its prognostic value resulted variable depending on the types of chronic HF patients. The highest prognostic information added by LV-GLS was in patients with normal SVI.
Study context
- Population
- Chronic heart failure (HF) outpatients with LVEF <50% and LV-GLS assessment
- Participants
- 351 outpatients
- Exposure
- Four echo-derived haemodynamic phenotypes; prognostic value of LV-GLS within each
- Outcome
- All-cause mortality and HF hospitalization
- Follow-up
- Median 3.3 years
Main finding
As reported in the abstract
- Haemodynamic model independently predicted primary outcome, with incremental prognostic information over LVEF
- P<0.001 for C-statistics
Observational data: associations, not effects.
Secondary outcomes
Prevalence of haemodynamic phenotypes
All-cause mortality and CV mortality
- Haemodynamic model independently predicted secondary outcomes, with incremental prognostic information over LVEF
- P < 0.001 for C-statistics
- LV-GLS HRs decreased from NO-NP to low output-RV dysfunction (LO-RVD) for every endpoint
Original publication
Combining echo-derived haemodynamic phenotypes and myocardial strain for risk stratification of chronic heart failure with reduced ejection fraction. Eur Heart J Cardiovasc Imaging. Published 5 July 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →