Congenital heart disease

Comparative Congenital Cardiac Catheterization Registry Analysis From the United States and Low- and Middle-Income Countries

JACC AdvPublished Comparative registry analysis

Authors' conclusion

The harmonized databases facilitated direct comparison of CCC practices, revealing more complex patients and resource-intensive procedures in C3PO, while the IQIC cohort demonstrated lower CMAE rates but a slightly higher mortality rate. These findings emphasize the need for further risk adjustment modeling for LMICs and identify areas to enhance global resource access and patient outcomes.

Study context

Population
Congenital cardiac catheterization procedures recorded in the U.S.-based Catheterization Project on Outcomes (C3PO) registry and the International Quality Improvement Collaborative-Congenital Heart Disease Catheterization Registry (IQIC-CHDCR) registry from low- and middle-income countries (LMICs), 2019 to 2022cases analyzed
Participants
28,957 vs 6,485
Exposure
Patient characteristics and outcomes of congenital cardiac catheterization (CCC) in C3PO vs IQIC-CHDCR
  • C3POn = 28,957
  • IQIC-CHDCRn = 6,485
Outcome
Single ventricle patients

Main finding

As reported in the abstract

Observational data: associations, not effects.

Further findings

High-risk procedures (procedural risk in congenital cardiac catheterization 3-5)

Procedure duration

Safety

Clinically meaningful adverse event (CMAE) · lower ratio in IQIC

risk-adjusted ratio 0.50 (0.39–0.62)

Mortality · comparable

Failure-to-rescue

OutcomeRisk-adjusted ratio (95% CI)
Severity level 4/5 eventsLower ratio in IQIC0.71 (0.52–0.96)

Original publication

Comparative Congenital Cardiac Catheterization Registry Analysis From the United States and Low- and Middle-Income Countries. JACC Adv. Published 20 March 2025. doi:10.1016/j.jacadv.2025.101649

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