Arrhythmias & electrophysiology
Comparison of far-field and peak frequency electrogram characteristics at the earliest activation sites during idiopathic ventricular arrhythmias: A novel index to predict ablation success
Authors' conclusion
The first component of the EGM at the earliest activation site may reflect a far-field recording from the site of origin of idiopathic VAs. A novel delta F-P EGM index may predict quick, successful endocardial ablation of outflow tract VAs.
Study context
- Population
- Patients with idiopathic ventricular arrhythmias (VAs) undergoing catheter ablation with high-density activation mapsVAs analysed · outflow tract VAs 77 · non-outflow tract VAs 34
- Participants
- 111 VAs from 104 patients patients
- Exposure
- EGM characteristics at the earliest activation site in VAs with vs without a successful elimination after a single radiofrequency delivery
- Outcome
- First deflection timing (outflow tract VAs)
Main finding
As reported in the abstract
- Similar for VAs with and without a successful elimination
Observational data: associations, not effects.
Further findings
ms
| Outcome | VAs with a successful elimination | VAs without a successful elimination | P value |
|---|---|---|---|
| Peak frequency timing, right ventricular outflow tractEarlier with successful elimination | −21 (range as printed −32 to −16 ms) | −11 (range as printed −20 to 0 ms) | P = 0.002 |
| Peak frequency timing, left ventricular outflow tractEarlier with successful elimination | −26 (range as printed −33 to −4 ms) | 0 (range as printed −6 to 10 ms) | P = 0.005 |
| Delta F-P, right ventricular outflow tractShorter with successful elimination | 7 (range as printed 5-13 ms) | 17 (range as printed 11-24 ms) | P < 0.001 |
| Delta F-P, left ventricular outflow tractShorter with successful elimination | 10 (range as printed 6-19 ms) | 22 (range as printed 20-27 ms) | P = 0.001 |
Correlation of delta F-P with time to elimination (outflow tract VAs)
- R
- 0.45
- P
- P = 0.01
Successful elimination with delta F-P of >22 ms (outflow tract VAs)
- None achieved a successful elimination
Non-outflow tract VAs
- No parameters were associated with a successful elimination
Original publication
Comparison of far-field and peak frequency electrogram characteristics at the earliest activation sites during idiopathic ventricular arrhythmias: A novel index to predict ablation success. Heart Rhythm. Published 11 September 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →