Composition of nocturnal hypoxaemic burden and its prognostic value for cardiovascular mortality in older community-dwelling men
Authors' conclusion
In community-dwelling older men, T90 is an independent predictor of CV mortality. T90 is not only a consequence of frank desaturations, but also reflects non-specific drifts in oxygen saturation, both contributing towards the association with CV death.
Study context
- Population
- Community-dwelling older men (MrOS Sleep study) with overnight oximetry from polysomnograms
- Participants
- 2,840 men
- Exposure
- Nocturnal hypoxaemic burden and cardiovascular (CV) mortality
- Outcome
- CV mortality
- Follow-up
- 8.8 ± 2.7 years
Methodological detailscommunity-dwelling
- Community-dwelling
Main finding
As reported in the abstract
CV death · 8.8 ± 2.7 years
- CV deaths
- 185 (6.5%)
- T90, univariate HR
- 1.21, P < 0.001
- ODI, univariate HR (not significant)
- 1.13, P = 0.06
- T90, adjusted for potential confounders, HR
- 1.16, P = 0.004
- T90 > 12 min, HR
- 1.59; P = 0.006
Observational data: associations, not effects.
Further findings
Composition of T90
- Percent of T90 variation attributable to non-specific drifts in oxygen saturation
- 20.7 (5.7-48.5)
- T90desaturation and T90non-specific individually associated with CV death; combining both did not improve prediction
Original publication
Composition of nocturnal hypoxaemic burden and its prognostic value for cardiovascular mortality in older community-dwelling men. Eur Heart J. Published 22 December 2018. doi:10.
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