Congenital Heart Disease Fetuses Have Decreased Mid-Gestational Placental Flow, Placental Malperfusion Defects, and Impaired Growth
Main finding · Mid-gestational UVVF indexed to fetal weightResult — go to the resultDecrease 15%Authors' conclusion
CHD (particularly single ventricle) fetuses have decreased mid-gestational placental blood flow, increased placental malperfusion defects, and impaired fetal growth. Placental MVM may influence impaired fetal growth in CHD.
Study context
- Population
- Congenital heart disease (CHD) fetuses, including those with single ventricle physiology, and controlsCHD fetuses, plus 36 controls · CHD fetuses 38 · single ventricle physiology (of the CHD fetuses) 28 · controls 36
- Participants
- 38 fetuses
- Comparison
- CHD fetuses compared to controls
- CHD fetusesn = 38
- Controlsn = 36
- Outcome
- Mid-gestational UVVF indexed to fetal weight
- Follow-up
- 2nd trimester
Main finding
As reported in the abstract
Decrease
15%
P < 0.01
Observational data: associations, not effects.
Further findings
Placental maternal vascular malperfusion (MVM) lesions · increased in CHD fetuses
P < 0.05
High-grade MVM
P = 0.05
Placental fetal vascular malperfusion lesions · trend toward increase in CHD fetuses
P = 0.10
| Outcome | Reduction | P value |
|---|---|---|
| UVVF as a proportion of fetal cardiac output · 2nd trimesterReduction in CHD fetuses compared to controls | 27% | P < 0.01 |
Birth weight in CHD fetuses by placental lesions
- Placental maternal vascular malperfusion (MVM) but not fetal vascular malperfusion lesions associated with decreased birth weight in CHD fetuses
- P < 0.001
Umbilical venous volume flow (UVVF) and placental pathologic findings or fetal growth
- No association between UVVF and placental pathologic findings or fetal growth
Original publication
Composed by AI from the published abstract and checked against it. How Briefs are made →