Placental Vascular Malperfusion in Pregnancies With Congenital Heart Disease: A Prospective Comparative Study
Authors' conclusion
Women with CHD had a higher prevalence of MVM compared to controls, which was associated with adverse pregnancy outcomes. However, no clinical or paraclinical risk factors for MVM were identified.
Study context
- Population
- Pregnant women with congenital heart disease (CHD) followed from March 2021 to June 2023, and matched controls without CHDPlacentas from 39 CHD and 67 control women were analyzed
- Participants
- 39 vs 67
- Exposure
- Prevalence of maternal vascular malperfusion (MVM) in pregnant women with CHD to those without CHD
- CHDn = 39
- Controlsn = 67
- Outcome
- MVM prevalence
Methodological detailscontrol group matched for age, parity, and body mass index
- Control group matched for age, parity, and body mass index
Main finding
As reported in the abstract
P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | RR | P value |
|---|---|---|
| Adverse obstetric and neonatal outcomesIndependently associated with MVM | 7.2 | P = 0.002 |
Adverse obstetric and neonatal outcomes
- CHD pregnancies had a higher incidence of adverse obstetric and neonatal outcomes
Risk factors for MVM in CHD women
- No clinical or paraclinical factors were associated with MVM in CHD women
Original publication
Placental Vascular Malperfusion in Pregnancies With Congenital Heart Disease: A Prospective Comparative Study. JACC Adv. Published 10 February 2025. doi:10.
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