Arrhythmias & electrophysiology
Copy number variation of gasdermin D gene is associated with atrial fibrillation-related thromboembolic stroke
Main finding · Ischaemic stroke risk, GSDMD homozygous deletion carriersResult — go to the resultOdds ratio 2.195 95% CI 1.24–3.90Authors' conclusion
We found a link between the homozygous deletion of the GSDMD gene and an increased risk of stroke in patients with AF.
Study context
- Population
- Patients with documented non-familial atrial fibrillation (AF)100 with ischaemic stroke
- Participants
- 400 patients
- Comparison
- Gasdermin D (GSDMD) homozygous deletion genotype vs other genotypes
- Stroken = 100
- Outcome
- Association of GSDMD deletion with AF-related ischaemic stroke
Methodological detailsBaseline age, sex, valvular heart disease, CAD, HF and CHA2DS2-VASc scores not statistically different between cases and controls
- Baseline age, sex, valvular heart disease, CAD, HF and CHA2DS2-VASc scores not statistically different between cases and controls
Main finding
As reported in the abstract
Ischaemic stroke risk, GSDMD homozygous deletion carriers
Odds ratio
2.195
95% CI 1.24–3.90
P = 0.007
GSDMD homozygous deletion genotypevs other genotypes
OR 2.195 (95% CI 1.24–3.90); P = 0.007
Observational data: associations, not effects.
Further findings
Validation in UK Biobank (Caucasian population)
- Association of GSDMD with AF stroke validated
Original publication
Copy number variation of gasdermin D gene is associated with atrial fibrillation-related thromboembolic stroke. Europace. Published 21 April 2023. doi:10.
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