Coronary Artery Calcium Density and Cardiovascular Events by Volume Level: The MESA
Authors' conclusion
The lower risk for CHD associated with higher CAC density varied by level of volume, and volume ≤130 mm3 is a potentially clinically useful cut point.
Study context
- Population
- MESA participants with detectable coronary artery calcium (CAC)detectable CAC
- Participants
- 3,316 participants
- Exposure
- CAC density, by CAC volume level (≤130 vs >130 mm³); CAC volume and density models vs Agatston score
- Outcome
- Coronary heart disease (CHD) (MI, CHD death, resuscitated cardiac arrest)
Methodological detailsanalysis of the MESA cohort, multivariable Cox regression
- Analysis of the MESA cohort
- Multivariable Cox regression
Main finding
As reported in the abstract
CHD risk per unit of CAC density, by CAC volume
Hazard ratio (95% CI)
Volume ≤130 mm³per unit of density
0.57(0.43–0.75)
Volume >130 mm³per unit of density; not significant
0.82(0.55–1.22)
Per unit of density, as printed
Observational data: associations, not effects.
Further findings
| Outcome | Volume and density | Agatston | Net reclassification improvement (95% CI) |
|---|---|---|---|
| CHD risk prediction: CAC volume and density models vs Agatston score | 0.208 (0.102–0.306) | ||
| C-index | 0.703, SE 0.012 | 0.687, SE 0.013 |
Original publication
Coronary Artery Calcium Density and Cardiovascular Events by Volume Level: The MESA. Circ Cardiovasc Imaging. Published 21 February 2023. doi:10.
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