Thoracic versus coronary calcification for atherosclerotic cardiovascular disease events prediction
Authors' conclusion
Our study demonstrated a significant association between TAC and CAC scores but a superior prognostic value of CAC score for ASCVD events.
Study context
- Population
- MESA Exam 5 participants who underwent both chest CT and ECG-gated cardiac CT; mean age 69±9 years, 47% male
- Participants
- 2,412 participants
- Exposure
- Thoracic artery calcium (TAC) on chest CT vs CAC on ECG-gated cardiac CT for atherosclerotic cardiovascular disease (ASCVD) prediction
- Outcome
- Incident ASCVD events:
- Prognostic value
- Time-dependent ROC
- Follow-up
- Median 8.8 years
Methodological detailsMESA Exam 5
- MESA Exam 5
Main finding
As reported in the abstract
Area under time-dependent ROC curve for ASCVD events
| Group | AUC |
|---|---|
| TAC | 0.641 |
| CAC | 0.698 |
AUC
TAC0.641
CAC0.698
- CAC vs TAC: P = 0.031 — CAC greater than TAC
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Association with ASCVD events (multivariable Cox regression)TACvs CACTAC score | 1.31 (1.09–1.58) | |
| 0.512Hazard ratio (log scale) |
Association with ASCVD events (multivariable Cox regression)
| HR (95% CI) | ||
|---|---|---|
| CACCAC score | 1.82 (1.53–2.17) | |
| 0.512Hazard ratio (log scale) |
Correlation between TAC and CAC scores
- Spearman correlation
- 0.46 (p<0.001)
Incident ASCVD events (all participants) · median follow-up 8.8 years
- Participants with ASCVD events
- 234 (9.7%)
Original publication
Thoracic versus coronary calcification for atherosclerotic cardiovascular disease events prediction. Heart. Published 16 April 2024. doi:10.
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