Coronary Inflammation and Plaque Vulnerability: A Coronary Computed Tomography and Optical Coherence Tomography Study
Authors' conclusion
Optical coherence tomography features of plaque vulnerability were significantly more common in patients with high PCAT attenuation, compared with those with low PCAT attenuation.
Study context
- Population
- Patients (198 ACS, 276 stable angina pectoris) undergoing preintervention coronary CT angiography and optical coherence tomography
- Participants
- 474 patients
- Exposure
- High vs low peri-coronary adipose tissue (PCAT) attenuation
- High PCAT attenuationn = 244
- Low PCAT attenuationn = 230reference
- Outcome
- Optical coherence tomography plaque characteristics (features of plaque vulnerability)
Main finding
As reported in the abstract
OCT features of plaque vulnerability
Lipid-rich plaque
P = 0.006
Macrophage
P = 0.041
Microchannels
P = 0.003
Plaque rupture
P < 0.001
Layered plaque
P = 0.025
Observational data: associations, not effects.
Further findings
Clinical characteristics
Male
P < 0.001
NSTEMI
P = 0.003
Stable angina pectoris
P = 0.003
EF
P = 0.014
HDL-C
P = 0.027
Clinical characteristics
- Aspirin, DAPT and statins less frequently used with high PCAT attenuation
Original publication
Coronary Inflammation and Plaque Vulnerability: A Coronary Computed Tomography and Optical Coherence Tomography Study. Circ Cardiovasc Imaging. Published 3 March 2023. doi:10.
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