Sex-Specific Association Between Perivascular Inflammation and Plaque Vulnerability
Authors' conclusion
Perivascular inflammation was associated with a higher prevalence of thin-cap fibroatheroma and more significant macrophage accumulation in women but not in men.
Study context
- Population
- Patients who underwent coronary CT angiography and optical coherence tomography; 82 women and 327 men
- Participants
- 409 patients968 lesions
- Exposure
- High vs moderate vs low perivascular inflammation, by sex
- Outcome
- Plaque vulnerability on optical coherence tomography (thin-cap fibroatheroma, macrophage grade), by sex
Methodological detailscore laboratory analysis, All images analysed at a core laboratory
- Core laboratory analysis
- All images analysed at a core laboratory
Main finding
As reported in the abstract
Thin-cap fibroatheroma prevalence and macrophage grade, women and men
| Group | Value | Macrophage grade (women) |
|---|---|---|
| Low inflammation | 18.5% | 3 |
| Moderate inflammation | 31.8% | 4 |
| High inflammation | 46.9% | 12 |
Value
Low inflammation18.5%
Moderate inflammation31.8%
High inflammation46.9%
Macrophage grade (women)
Low inflammation3
Moderate inflammation4
High inflammation12
- High inflammation vs Low inflammation: P = 0.002 — women, thin-cap fibroatheroma
- High inflammation vs Low inflammation: P < 0.001 — women, macrophage grade
Observational data: associations, not effects.
Further findings
Age, women vs men
P < 0.001
Age, women vs men
- Women had less severe CAD with lower plaque burden than men
Original publication
Sex-Specific Association Between Perivascular Inflammation and Plaque Vulnerability. Circ Cardiovasc Imaging. Published 20 February 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →