Valvular & structural heart disease
Correlates and prognostic implications of left ventricular ejection fraction (LVEF) reduction after transcatheter edge-to-edge repair for primary mitral regurgitation
Main finding · Death, HF readmission and their composite by LVEF reduction at 1 monthResult — go to the resultHazard ratio 0.28 95% CI 0.10–0.78Authors' conclusion
LVEF reduction at 1-month post-TEER for primary MR is associated with better clinical outcomes, possibly reflecting a more pronounced unloading effect of the procedure.
Study context
- Population
- Patients with primary mitral regurgitation (MR) treated with isolated, first-time transcatheter edge-to-edge repair (TEER) with successful clip deployment; median age 83 years
- Participants
- 317 patients
- Exposure
- LVEF reduction vs no LVEF reduction at 1 month after TEER
- LVEF reductionn = 212
- Outcome
- All-cause mortality and HF hospitalizations
- Follow-up
- 2 years
Main finding
As reported in the abstract
Death, HF readmission and their composite by LVEF reduction at 1 month
Hazard ratio
0.28
95% CI 0.10–0.78
P = 0.016
LVEF reductionvs No LVEF reduction
HR 0.28 (95% CI 0.10–0.78); P = 0.016
Observational data: associations, not effects.
Further findings
Post-procedural MR, transmitral mean pressure gradient, functional status
- Comparable in the two groups
Filling pressures (intra-procedural); LV mass index, pulmonary arterial systolic pressure, natriuretic peptide (1 month); walking limitation (1 year)
- Greater decline with LVEF reduction
Original publication
Correlates and prognostic implications of LVEF reduction after transcatheter edge-to-edge repair for primary mitral regurgitation. Eur Heart J Cardiovasc Imaging. Published 17 August 2023. doi:10.
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