Arrhythmias & electrophysiology
Correlation Between Functional Substrate Mapping and Cardiac Computed Tomography–Derived Wall Thinning for Ventricular Tachycardia Ablation
Authors' conclusion
Wall thinning is highly sensitive for functional substrate in ICM patients. WTCs had modest sensitivity for functional substrate but low positive predictive value for identifying DZs in ICM and NICM patients.
Study context
- Population
- Patients with ICM or NICM undergoing ventricular tachycardia (VT) ablation with preprocedure CT angiography
- Participants
- 34 patients
- Comparison
- CTA-derived wall thinning and wall thickness channels (WTCs) vs functional substrate mapping
- ICMn = 21
- NICMn = 13
- Outcome
- Spatial correlation of CTA-derived wall thinning and WTCs with deceleration zones on LV endocardial isochronal late activation maps
Main finding
As reported in the abstract
Localisation of DZs relative to wall thinning and WTCs
| Group | Primary deceleration zones (DZs) on wall thinning | DZs near WTCs | PPV of WTC for DZs | DZs on wall thinning | DZs on wall thinning if any wall thinning present |
|---|---|---|---|---|---|
| ICM | 94.1% | 59% | 22.5% | ||
| NICM | 56% | 37.8% | 20% | 50% |
Primary deceleration zones (DZs) on wall thinning
ICM94.1%
NICMNot reported in the abstract
DZs near WTCs
ICM59%
NICM56%
PPV of WTC for DZs
ICM22.5%
NICM37.8%
DZs on wall thinning
ICMNot reported in the abstract
NICM20%
DZs on wall thinning if any wall thinning present
ICMNot reported in the abstract
NICM50%
- ICM vs NICM: P < 0.001 — greater surface areas of wall thinning in ICM
Original publication
Correlation Between Functional Substrate Mapping and Cardiac Computed Tomography–Derived Wall Thinning for Ventricular Tachycardia Ablation. JACC Clin Electrophysiol. Published 19 July 2023. doi:10.
Summarised from the published abstract; every number is checked against it