Arrhythmias & electrophysiology
Cryoballoon Pulmonary Vein Isolation With Versus Without Additional Right Atrial Linear Ablation for Persistent Atrial Fibrillation: The CRALAL Randomized Clinical Trial
Authors' conclusion
Additional RA linear ablation beyond Cryo-PVI improved the ablation outcome compared with that of PVI alone in persistent AF patients.
Study context
- Population
- Persistent atrial fibrillation (AF) refractory to antiarrhythmic drug therapy
- Participants
- 289 participants
- Comparison
- Cryoballoon PVI (Cryo-PVI) with additional right atrium (RA) linear ablation vs Cryo-PVI alone
- Primary endpoint
- Any documented atrial arrhythmia lasting ≥30 seconds after a 3-month blanking period after ablation
- Follow-up
- Median 24 months
Methodological detailsinvestigator-initiated, multicentre
- Investigator-initiated
- Multicentre
Primary result
As reported in the abstract
Atrial arrhythmia recurrence
Each group vs Cryo-PVI aloneAbsolute difference (95% CI)
Additional RA ablation
−15.6%(−27.9% to −3.4%)
Each group vs Cryo-PVI aloneHazard ratio (95% CI)
Additional RA ablation
0.66(0.46–0.94)
Secondary outcomes
Antiarrhythmic drugs prescribed after the 3-month period
Total procedure time · longer with additional RA ablation
P < 0.001
Safety
- No difference in complication rate between the 2 groups
Original publication
Cryoballoon Pulmonary Vein Isolation With Versus Without Additional Right Atrial Linear Ablation for Persistent Atrial Fibrillation: The CRALAL Randomized Clinical Trial. Circ Arrhythm Electrophysiol. Published 19 December 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →