Cardiovascular impact of near complete estrogen deprivation in premenopausal women with breast cancer: The CROWN study
Study context
- Population
- Premenopausal women with breast cancerplanned cohort
- Participants
- 90 women
- Exposure
- Near-complete estrogen deprivation (NCED) therapy vs comparators with HR-negative disease
- NCEDn = 67
- Comparatorsn = 23reference
- Outcome
- Change in myocardial perfusion reserve (myocardial prefusion reserve (MPR)) between the two groups
- Follow-up
- 2-year study period
Methodological detailsstudy design and rationale, three-site regional, serial stress cardiac magnetic resonance (CMR) and cardiac CT angiography, Accrual expected to complete in December 2024, Three annual CMR scans and 2 cardiac computed tomography angiography (CCTA) scans during the 2-year study
- Study design and rationale
- Three-site regional
- Serial stress CMR and cardiac CT angiography
- Accrual expected to complete in December 2024
- Three annual CMR scans and 2 CCTA scans during the 2-year study
Main finding
As reported in the abstract
- No results reported; primary outcome to be reported in 2026 to 2027
Observational data: associations, not effects.
Original publication
Cardiovascular impact of near complete estrogen deprivation in premenopausal women with breast cancer: The CROWN study. Am Heart J. Published 26 October 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →