Arrhythmias & electrophysiology
Cryoballoon Ablation for Atrial Fibrillation in Patients with Heart Failure with Mildly Reduced and Preserved Ejection Fraction
Authors' conclusion
Patients with HFmrEF and HFpEF could benefit from CBA with high SR maintenance and significant HF improvement.
Study context
- Population
- Consecutive patients with atrial fibrillation (AF) referred for cryoballoon ablation-based pulmonary vein isolation (PVI) at two experienced electrophysiology centresof 651 undergoing cryoballoon ablation (CBA)
- Participants
- 471 patients
- Exposure
- CBA-based PVI for AF across heart failure (HF) categories
- No HFn = 255reference
- HFpEFn = 101
- HFmrEFn = 78
- HF with reduced ejection fractionn = 37
- Outcome
- Long-term SR maintenance
Methodological detailstwo centres
- Two centres
Main finding
As reported in the abstract
- No significant difference among HFmrEF, HFpEF and No HF
- P = 0.334
Observational data: associations, not effects.
Further findings
| Outcome | No HF | HFpEF | HFmrEF |
|---|---|---|---|
| Early recurrence of atrial arrhythmia | 16.2% | 15.4% | 14.9% |
- Early recurrence of atrial arrhythmia — Similar among groups
- P = 0.798
- Early recurrence of atrial arrhythmia: HFrEF 12.2%
Cardiac function after CBA
- HFpEF patients completely relieved from HF
- 41.6%
- Left atrial diameter (LAD) and LVEF significantly improved in HFmrEF
Predictors
- LAD and New York Heart Association (NYHA) associated with recurrence in HFpEF and HFmrEF
- Sinus rhythm (SR) maintenance independent predictor of NYHA improvement in all HF groups
Safety
| Outcome | No HF | HFpEF | HFmrEF |
|---|---|---|---|
| Complications | 3.1% | 4.0% | 3.8% |
- Complications — Similar complications
- P = 0.814
Original publication
Cryoballoon Ablation for Atrial Fibrillation in Patients with Heart Failure with Mildly Reduced and Preserved Ejection Fraction. ESC Heart Fail. Published 3 November 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →