Cumulative Burden of Geriatric Conditions and Cardiovascular Outcomes in Older Adults: Analysis From ARIC
Main finding · MACEResult — go to the resultOdds ratio 4.26 95% CI 3.17–5.83Authors' conclusion
In a community-based cohort, we observed a graded and synergistic association between the number of geriatric conditions and MACE.
Study context
- Population
- Older adults in the ARIC (Atherosclerosis Risk In Communities) study
- Exposure
- Number of geriatric conditions
- Outcome
- MACE:
- All-cause death
- Acute MI
- Stroke
Methodological detailscommunity-based cohort
- Community-based cohort
Main finding
MACE
Odds ratio
4.26
95% CI 3.17–5.83
By group
≥5vs 0-1
OR 4.26 (95% CI 3.17–5.83)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | |
|---|---|---|
| MI, stroke, death≥5vs 0-1MI | 4.62 (2.92–7.72) | |
| MI, stroke, death≥5vs 0-1Stroke | 6.03 (3.04–13.75) | |
| MI, stroke, death≥5vs 0-1Death | 3.12 (2.12–4.74) | |
| 0.050.21520Odds ratio (log scale) |
Original publication
Cumulative Burden of Geriatric Conditions and Cardiovascular Outcomes in Older Adults: Analysis From ARIC. JACC Adv. Published 12 November 2025. doi:10.
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