Valvular & structural heart disease
Transcatheter edge-to-edge repair for chronic functional mitral regurgitation in patients with very severe left ventricular dysfunction
Authors' conclusion
TEER for chronic FMR is feasible, safe, and efficacious in selected patients with very severe LVD.
Study context
- Population
- Patients with chronic functional mitral regurgitation and very severe LV dysfunction (left ventricular ejection fraction (LVEF) <20%)
- Participants
- 96 patients
- Outcome
- All-cause mortality or HF hospitalisation
- Follow-up
- 1 year
Methodological detailsconsecutive patients, single-group, 47 (49.0%) urgent or with hemodynamic instability
- Consecutive patients
- Single-group
- 47 (49.0%) urgent or with hemodynamic instability
Main finding
As reported in the abstract
Freedom from all-cause mortality or HF hospitalization
Freedom from the primary outcome at 1 year
50.0%
Observational data: associations, not effects.
Further findings
Survival · 1 year
- One-year survival
- 74.0%
Technical success
- Technically successful procedures
- 98.0%
≤moderate MR · 1 month and 1 year
- ≤moderate MR at 1 month
- 94.7%
- ≤moderate MR at 1 year
- 90.7%
NYHA class ≤II
- NYHA class ≤II maintained
- 60.0%
Functional and echocardiographic improvement vs baseline
- Independent of procedural urgency, hemodynamic stability and downstream LV assist device implantation / heart transplantation (n = 12)
Risk prediction
- Mortality not predicted by COAPT exclusion criteria; primary outcome not discriminated by published risk models
Original publication
Transcatheter edge-to-edge repair for chronic functional mitral regurgitation in patients with very severe left ventricular dysfunction. Am Heart J. Published 4 June 2023. doi:10.
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