Valvular & structural heart disease
Long-term risk of atrial fibrillation or flutter after transcatheter patent foramen ovale closure: a nationwide Danish study
Authors' conclusion
Patent foramen ovale closure was not associated with any substantial increased long-term risk of developing AF beyond the well-known procedure-related short-term risk.
Study context
- Population
- Danish nationwide cohorts with patent foramen ovale (PFO) closure, PFO diagnosis or matched general population, 2008–2020
- Participants
- 817 / 1,224 / 8,170
- Exposure
- PFO closure vs PFO diagnosis without closure vs matched general population
- PFO closuren = 817
- PFO diagnosisn = 1,224reference
- Matchedn = 8,170reference
- Outcome
- First-time AF (atrial fibrillation or flutter) diagnosis
Methodological detailsmatched 10:1 general population comparison cohort on age and sex, multivariable-adjusted
- Matched 10:1 general population comparison cohort on age and sex
- Multivariable-adjusted
Main finding
As reported in the abstract
AF
Hazard ratio (95% CI)
PFO closurevs PFO diagnosiswithin the first 3 months
2.3(1.3–4.0)
PFO closurevs PFO diagnosisafter 3 months
0.7(0.3–1.7)
PFO closurevs Matchedwithin the first 3 months
51(21–125)
PFO closurevs Matchedafter 3 months
2.5(1.2–5.0)
Observational data: associations, not effects.
Original publication
Long-term risk of atrial fibrillation or flutter after transcatheter patent foramen ovale closure: a nationwide Danish study. Eur Heart J. Published 3 June 2023. doi:10.
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