Aortic & peripheral vascular disease
D-Dimer, C-Reactive Protein and Matrix Metalloproteinase 9 for Prediction of Type a Aortic Dissection Patient Survival
Authors' conclusion
Combined measurement of CRP, d-dimer, and MMP9 is associated with 1 year of survival in patients with ATAAD.
Study context
- Population
- Patients with acute type A aortic dissection (ATAAD) who underwent surgery
- Participants
- 247 patients
- Exposure
- Non-survivors vs survivors at 1 year; combined C-reactive protein (CRP), d-dimer and MMP9 model for prediction of death
- Non-survivorsn = 89
- Survivorsn = 158reference
- Outcome
- Prediction of survival by preoperative CRP, d-dimer and MMP9 (combined detection model)
- Follow-up
- 1 year after surgery
Main finding
As reported in the abstract
Prediction of 1-year survival (ROC analysis)
| Group | AUC |
|---|---|
| Combined CRP + d-dimer + MMP9 model | 0.88 |
Combined CRP + d-dimer + MMP9 model
AUC0.88
Observational data: associations, not effects.
Further findings
Baseline characteristics, non-survivors vs survivors
- Non-survivors had higher age, hypertension prevalence, SBP, white blood cell count, CRP, d-dimer and MMP9
Preoperative CRP, d-dimer and MMP9, ATAAD vs healthy controls
- Significantly higher in ATAAD than in healthy controls
Correlations between biomarkers in ATAAD
- Positive correlations between CRP and d-dimer, CRP and MMP9, and d-dimer and MMP9
Original publication
D-Dimer, C-Reactive Protein and Matrix Metalloproteinase 9 for Prediction of Type a Aortic Dissection Patient Survival. ESC Heart Fail. Published 17 October 2023. doi:10.
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