Heart failure & cardiomyopathiesMechanistic study
Deceived by the Fick principle: blood flow distribution in heart failure
- Mechanistic study
Authors' conclusion
The bulk of these data suggests that blood flow distribution plays a pivotal role on peakV̇O2 determination regardless of HF treatment strategies.
Study context
- Population
- Heart failure (HF) patients before and 6 months after exercise training, CRT or percutaneous edge-to-edge mitral valve repair468 tests
- Participants
- 234 patients
- Comparison
- Group 1 vs Group 2 vs Group 3
- Group 1n = 93
- Group 2n = 60
- Group 3n = 81
Main finding
As reported in the abstract
Correlation of post-treatment peakQc vs peakΔC(a-v)O2 changes · 6 months after treatment
| Group | R2 |
|---|---|
| Group 1 | 0.64 |
| Group 2 | 0.79 |
| Group 3 | 0.58 |
- Close negative correlation between peakQc and peakΔC(a-v)O2 changes, all patients (R2)
- 0.46
- Patients with diverging peakQc and ΔC(a-v)O2 changes, regardless of treatment
- 76%
Original publication
Deceived by the Fick principle: blood flow distribution in heart failure. Eur J Prev Cardiol. Published 27 June 2024. doi:10.1093/eurjpc/zwae203
Summarised from the published abstract; every number is checked against it