Derivation and validation of the ISAR score to predict the risk of repeat percutaneous coronary intervention for recurrent drug-eluting stent restenosis
Main finding · Discrimination (C-statistic) for repeat PCI for recurrent DES-ISRResult — go to the resultDelta C-statistic 0.062 95% CI 0.035–0.094Authors' conclusion
This study developed and validated a risk prediction model for repeat PCI for recurrent DES-ISR at 1-year follow-up.
Study context
- Population
- Consecutive patients treated with percutaneous coronary intervention (PCI) for drug-eluting stent (DES) in-stent restenosis (ISR) at 2 centres in Germanytraining 1,471
- Participants
- 1,986 patients
- Exposure
- ISAR prediction model vs benchmark ISR classification model
- Outcome
- Repeat PCI for recurrent DES-ISR
- Follow-up
- Up to 1 year
Methodological detailsobservational, 2 centres in Germany, training and validation cohorts, bootstrap resampling
- Observational
- 2 centres in Germany
- Training and validation cohorts
- Bootstrap resampling
Main finding
As reported in the abstract
Discrimination (C-statistic) for repeat PCI for recurrent DES-ISR
Delta C-statistic
0.062
95% CI 0.035–0.094
P < 0.001
By group
ISAR model
0.60
C-statistic · 95% CI 0.57–0.63
Benchmark ISR classification
0.54
C-statistic · 95% CI 0.52–0.57
Observational data: associations, not effects.
Further findings
Cumulative incidence of repeat PCI for recurrent DES-ISR by ISAR score
- Over three times higher with ISAR score ≥3 vs score 0
Original publication
Derivation and validation of the ISAR score to predict the risk of repeat percutaneous coronary intervention for recurrent drug-eluting stent restenosis. EuroIntervention. Published 3 April 2023. doi:10.
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