Design of a multi-institutional neurocognitive discovery study in adult congenital heart disease (Multi-Institutional Neurocognitive Discovery Study in Adults with Congenital Heart Disease (MINDS-ACHD))
Study context
- Population
- Young adults aged 18–30 years with moderate or severe complexity CHD at 14 centres in North Americaenrolling (planned)
- Participants
- 500 adults
- Planned comparison
- d-TGA vs Tetralogy of Fallot (TOF) vs single ventricle (SV) vs Other
- d-TGAn = 125
- TOFn = 125
- SVn = 125
- Othern = 125
Methodological detailsmulticentre, pilot, design paper, Tests: NIH Toolbox Cognitive Battery, NeuroQoL, Hospital Anxiety and Depression Scale, PROMIS Global QoL; optional biospecimen for genetic analysis, Remote participation permitted due to COVID-19; tests reviewed by a Neurocognitive Core Laboratory
- Multicentre
- Pilot
- Design paper
- Tests: NIH Toolbox Cognitive Battery, NeuroQoL, Hospital Anxiety and Depression Scale, PROMIS Global QoL; optional biospecimen for genetic analysis
- Remote participation permitted due to COVID-19; tests reviewed by a Neurocognitive Core Laboratory
No results yet. This paper sets out the design of a trial; its results are to come.
Original publication
Design of a multi-institutional neurocognitive discovery study in adult congenital heart disease (MINDS-ACHD). Am Heart J. Published 20 April 2023. doi:10.
Summarised from the published abstract; every number is checked against it