Deterioration in Renal Function in Patients With a Fontan Circulation and Association With Mortality
Authors' conclusion
Declines in eGFRcr in patients with Fontan circulation are more rapid than in healthy individuals. Higher baseline NT-proBNP z-scores are associated with a more rapid deterioration of eGFRcr, and eGFRcr deterioration is associated with mortality.
Study context
- Population
- Patients with a Fontan circulation
- Participants
- 82 patients
- Outcome
- All-cause mortality (survival analyses)
Main finding
As reported in the abstract
11-year period
Mean eGFRcr decline per year, faster than healthy Dutch cohort
1.36 ml/min/1.73 m²/year
Observational data: associations, not effects.
Further findings
Renal dysfunction at baseline (eGFR <90 ml/min/1.73 m²)
- Renal dysfunction by eGFRcr
- 12%
- Renal dysfunction by eGFRcys
- 24%
Factors associated with eGFRcr decline
- Higher baseline N-terminal prohormone of brain natriuretic peptide (NT-proBNP) z-scores associated with more rapid eGFRcr decline
Age at baseline
- Median age (IQR 14-27 years)
- 20 years
Original publication
Deterioration in Renal Function in Patients With a Fontan Circulation and Association With Mortality. JACC Adv. Published 19 November 2024. doi:10.
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