Systemic Sirolimus Therapy Is Associated With Reduced Intervention Frequency in Pulmonary Vein Stenosis
Authors' conclusion
SST was associated with a reduction in frequency of PVS interventions.
Study context
- Population
- Patients with moderate to severe pediatric pulmonary vein stenosis (PVS) treated with systemic sirolimus therapy (SST) for ≥1 month, 2015–2022
- Participants
- 45 patients
- Exposure
- On-SST vs pre-SST intervals
- Outcome
- PVS intervention rate (interventions/year)
Methodological detailspaired pre-SST vs on-SST intervals, generalized Poisson mixed models
- Paired pre-SST vs on-SST intervals
- Generalized Poisson mixed models
Main finding
As reported in the abstract
Median per-patient PVS intervention rate (interventions/year)
P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Cumulative number of interventions over time (mean cumulative function)Increased cumulative number pre-SST | P < 0.001 |
Duration of SST and follow-up
Years
- Median duration of SST
- 1.7
- Median follow-up from SST initiation
- 2.7
Mortality · median 1.1 years (range, 4.4 months-6.5 years) after SST initiation
- Deaths
- 6
Original publication
Systemic Sirolimus Therapy Is Associated With Reduced Intervention Frequency in Pulmonary Vein Stenosis. JACC Adv. Published 15 November 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →