Acute cardiac care & resuscitation
Development and validation of a risk score in acute myocardial infarction-related cardiogenic shock
Authors' conclusion
A prediction model was developed and externally validated using data from two large national registries. The model demonstrated good performance and is suitable for clinical decision-making and quality purposes in AMICS.
Study context
- Population
- Patients with acute myocardial infarction-related cardiogenic shock (AMICS) undergoing percutaneous coronary intervention in The Netherlands (development) and Denmark (validation)development cohort, external validation cohort 1393 · development cohort (2017 to 2021, Netherlands Heart Registration) 2,261 · external validation cohort (2010-2017, Danish Retroshock registry) 1,393
- Participants
- 2,261 patientsEvents: 886 (39%)
- Predictors
- Initial lactate, glucose, renal function, haemoglobin, age, blood pressure, heart rate, intubation prior to PCI, intervention in the left main coronary artery, and successful revascularization
- Predicted outcome
- 30-day mortality
Methodological detailsdevelopment and external validation of a prediction model, two national registries
- Development and external validation of a prediction model
- Two national registries
Model performance
As reported in the abstract
AUC
Initial model (development cohort)
0.81(0.79-0.83)
External validationexternal validation (Danish Retroshock registry)
0.73(0.70-0.76)
Further findings
Development cohort characteristics
- Median age
- 67 years [interquartile range (IQR) 58-75]
- Male
- 1649 (73%)
External validation cohort characteristics and 30-day mortality
- Male
- 1050 (75%)
- Median age
- 67 years (IQR 59-75)
- 30-day mortality rate
- 49% (n = 680)
Original publication
Development and validation of a risk score in acute myocardial infarction-related cardiogenic shock. Eur Heart J Acute Cardiovasc Care. Published 25 March 2025. doi:10.
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