Acute cardiac care & resuscitation
Frailty and Age as Predictors of Mortality in Acute Myocardial Infarction Complicated by Cardiogenic Shock
Authors' conclusion
Frailty and age are strong, independent predictors of mortality in AMICS.
Study context
- Population
- Patients with acute MI complicated by cardiogenic shock (AMICS), RETROSHOCK cohort, Denmark, 2010–2017
- Participants
- 1,716 patients
- Exposure
- Frail vs nonfrail; age categories
- Frailn = 381
- Outcome
- Mortality
- Follow-up
- 30 days, 1 year (30-day landmark) and 10 years (30-day landmark)
Methodological details2 tertiary university hospitals in Denmark
- 2 tertiary university hospitals in Denmark
Main finding
As reported in the abstract
30-day mortality · 30 days
P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | Values | Adjusted HR (95% CI) | P value | |
|---|---|---|---|---|
| 30-day mortality by age (highest in age ≥80 years) · 30 days≥80 years vs Nonfrail <50 years | ≥80 years 82% | 9.18 (4.66–18.1) | P < 0.001 | |
| 0.050.21520Adjusted hazard ratio (log scale) |
- 30-day mortality by age (highest in age ≥80 years): P < 0.001 for highest mortality at age ≥80 years
Mortality, combined age and frailty: frail ≥70 years · 30 days; 10 years (30-day landmark)
- Frail ≥70 years, 30-day mortality
- 73%
- Frail ≥70 years, 10-year mortality (30-day landmark)
- 82%
Original publication
Frailty and Age as Predictors of Mortality in Acute Myocardial Infarction Complicated by Cardiogenic Shock. JACC Adv. Published 17 September 2025. doi:10.
Summarised from the published abstract; every number is checked against it